When you hear hoof beats, don’t forget the zebra: The role of nonserous ovarian cancer in BRCA mutation carriers

Objective: The predominance of high-grade serous ovarian carcinoma in BRCA mutation carriers has been previously documented, but recent studies suggest that BRCA mutations are confined exclusively to this histologic subtype. Our study objectives were to characterize the histologic subtypes of ovarian, fallopian tube (FT), and primary peritoneal (PP) cancers in a cohort of known BRCA1 and BRCA2 mutation carriers and to correlate with family history and cancer outcome.