The study of the association of the p35 rs17852832 SNP polymorphism with Alzheimer’s disease

Background Alzheimer’s disease (AD) may be caused by multiple factors, including genetics, age, environment etc. At present, AD associated genes are: gene App, ps1, ps2 and apoE. However, these associated genes account mainly for the abnormal increase and accumulation of Ab, rather than the molecular genetic mechanism for the formation of neurofibrillary tangles and neuronal loss. P35 is a neuron specific regulative unit of CDK5. p35 gene contain several SNPs, and at some SNPs sites, the change of as ingle base results in the corresponding change of P35 amino acids. Cleavage of P35 into P25 greatly increases the kinase activity of CDK5, which in turn abnormally phosphorylates tauprotein, and then contributes to the formation of neurofibrillary tangles. What we are interested in is whether the polymorphism of the P35 gene was involved in the pathogenesis of AD. There are few research reports about the relationship of the P35 gene polymorphism with AD. Methods