Myocardial perfusion is impaired in renal transplant and liver transplant patients

Methods We conducted a prospective study of 25 renal transplant (RT) recipients, 8 liver transplant (LT) recipients without previous CKD history and 7 controls with hypertension (HT). The transplant recipients were asymptomatic and had no previous ischaemic heart disease or revascularisation or systolic heart failure. The pre-transplant workup of the RT and LT were negative for haemodynamically significant epicardial coronary artery stenosis. Diabetes mellitus history between RT, LT and HT controls were not statistically different. Myocardial function, late-gadolinium enhancement and first-pass perfusion was assessed semiquantitatively at rest and under stress. The MPRI was calculated as the ratio of perfusion during adenosine-induced hyperemia to the rest perfusion. The RT and LT patients underwent whole-heart non-contrast magnetic resonance coronary angiography (MRCA) to assess the presence of proximal to mid epicardial coronary artery disease.