The iPLA 2 γ is identified as the membrane potential sensitive phospholipase in liver mitochondria

•R-BEL inhibits the Δψ sensitive iPLA2 activity in rat liver mitochondria.•Mouse mitochondria contain a Δψ sensitive iPLA2 activity that is inhibited by BEL.•iPLA2β knockout animals have activity similar to wild type in the presence of CCCP.•A substantial decrease in Δψ sensitive activity was observed in iPLA2γ KO animals.•The iPLA2 isozyme responsible for Δψ sensitive iPLA2 activity is the iPLA2γ.