Hypoxia inducible factor 1α down regulates cell surface expression of α1,2-fucosylated glycans in human pancreatic adenocarcinoma cells

•PDAC and colon cancer (CRC) cell lines constitutively express HIF-1α.•HIF-1α inhibition enhances cell surface α1,2-fucosylation on PDAC and CRC cells.•Inhibition of HIF-1α enhances FUT1 and FUT2 transcripts in PDAC and CRC cells.•Knock down of HIF-1α increases FUT1/2 expression and α1,2-fucosylation in PaTu-T.•HIF-1α suppresses FUT1/2 expression, thus regulating cell surface α1,2-fucosylation.