Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition
FEBS Letters(2015)
Abstract
•The protein level of IKZF1 is reduced by kinase inhibitors.•Kinase inhibition reduces IKZF1 ubiquitination but does not increase its stability.•IKZF1 is degraded through apoptosis induced by kinase inhibitors in myeloma cells.
MoreTranslated text
Key words
CDKs,CHX,CK2,CQ,CRBN,RING,CRL4,DDB1,ROC1,DRB,EDTA,FBS,GAPDH,GFP,GSK3,IMiDs,Len,PARP1,Rosc,SDS,Tris–HCl,TBST,UPP
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined