Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition

Yaobin Liu,Xian He,Yiyan Sui,Rong Yu,Guoqiang Xu

FEBS Letters（2015）

Cited 8|Views9

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Abstract

•The protein level of IKZF1 is reduced by kinase inhibitors.•Kinase inhibition reduces IKZF1 ubiquitination but does not increase its stability.•IKZF1 is degraded through apoptosis induced by kinase inhibitors in myeloma cells.

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Key words

CDKs,CHX,CK2,CQ,CRBN,RING,CRL4,DDB1,ROC1,DRB,EDTA,FBS,GAPDH,GFP,GSK3,IMiDs,Len,PARP1,Rosc,SDS,Tris–HCl,TBST,UPP

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