Opposite NOS2-Mediated Roles for Epidermal Growth Factor and Indomethacin in Immature Human Intestinal Inflammation

its binding to FPR1.Conclusion: These findings show that synthetic gliadin peptides induce neutrophil migration in an FPR1-dependent manner.The present study emphasizes an emerging concept that PT-gliadin is interpreted and handled by the host mucosa as a danger signal similar to that provided by fMet-Leu-Phe, likewise exerting direct and robust chemoattractant effects on neutrophils.These observations provide new insight into our understanding of how gliadin triggers inflammatory and autoimmune responses.