Homeostasis Model Assessment-Insulin Resistance and Metabolic Syndrome Components As Risk Factors for Colorectal Adenoma

tumor molecular data, we performed analyses stratified by tumoral microsatellite instability (MSI), CpG island methylator phenotype (CIMP), long interspersed nucleotide element-1 methylation, and BRAF, KRAS, and PIK3CA mutations.RESULTS: Among 1550 CRC cases followed-up over median 13.9 years, there were 599 deaths, of which 173 were attributable to colorectal cancer.No difference in CRC-specific or overall survival time was observed according to quintile of post-diagnosis folate (multi-group Log-Rank P.0.3).Similarly, in multivariate Cox regression models, folate intake was not associated with mortality (CRCspecific mortality HR=0.98; 95% CI, 0.59-1.64 for highest vs. lowest quintile; P trend for increasing folate =0.48).No differential associations between folate and survival were observed in subset analyses of 685 tumors with available molecular data ( P interaction all .0.3).CONCLUSIONS: Higher post-diagnosis folate intake is not associated with adverse outcome in stage I-III CRC.Our findings do not support the hypothesis that higher folate intake might promote the aggressiveness of established CRC.Diets rich in folate may be acceptable for patients with a history of CRC.