Su1879 SIRT1 Antagonizes Distinct Effects of TNF-α on Intestinal Epithelial Barrier

G A A b st ra ct s with siRNA os-9 obviously decreased the TER (806.6±49.9V/cm2). Consistently, os-9 knockdown in hypoxia significantly reduced the TER (333.3±31.5V/cm2) compared to in hypoxia only (736.6±39.8V/cm2). Conclusion: Os-9 knockdown significantly aggratated hypoxiainduced intestinal epithelium injury. These findings indicate that os-9 may play an important role in maintaining the epithelial barrier function through occludin and claudin-1.