Propofol-induced rno-miR-665 targets BCL2L1 and influences apoptosis in rodent developing hippocampal astrocytes

•Propofol exerts cytotoxic effects on immature hippocampal astrocytes via miRNAs.•Rno-miR-665 targeted genes are mostly related to CNS development and cell fate.•Rno-miR-665 targets anti-apoptotic BCL2L1 under caspase-3-mediated mechanism.•Downregulation of rno-miR-665 protects astrocytes from propofol-induced apoptosis.