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A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam

Lorenzo Di Cesare Mannelli,Mario Maresca,Carlo Farina,Michael W. Scherz,Carla Ghelardini

NeuroToxicology（2015）

Cited 12|Views6
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Abstract
•Sorafenib induces hypersensitivity to a cold non noxious stimulus in the rat.•Sorafenib i.p. administration is more efficient than p.o., s.c. and e.v. routes.•Dimiracetam and pregabalin are effective against sorafenib-induced pain in the rat.
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Key words
Chemotherapy-induced neuropathy,Neuropathic pain,Sorafenib,Dimiracetam,Pregabalin,Pain model
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