Optimisation of a micro-neutralisation assay and its application in antigenic characterisation of influenza viruses.
INFLUENZA AND OTHER RESPIRATORY VIRUSES(2015)
摘要
Our study demonstrates that the improved MN assay has certain advantages over the HI assay: it is not significantly influenced by the cell-selected amino acid substitutions in the neuraminidase (NA) of A(H3N2) viruses, and it is particularly useful for antigenic characterisation of viruses which either grow to low HA titre and/or undergo an abortive infection resulting in an inability to form plaques in cultured cells.
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关键词
Antigenicity,haemagglutination inhibition,influenza,micro-neutralisation
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