Purification of TNFR-Fc produced in recombinant CHO cells: Characterization of product-related impurities

Process Biochemistry（2015）

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摘要

•TNFR-Fc was produced in CHO cell cultures with undesired multiple impurities.•The product-related impurities of TNFR-Fc were identified as N-terminally deleted fragments and scrambled disulfides.•The product-related impurities showed greatly reduced TNF-α neutralizing activity.

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关键词

CHO cells,TNFR-Fc,Product-related impurity,Disulfide bond

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