Mutation signatures implicate aristolochic acid in bladder cancer development

Song Ling Poon,Mi Ni Huang,Yang Choo,John R McPherson,Willie Yu,Hong Lee Heng,Anna Gan,Swe Swe Myint,Ee Yan Siew,Lian Dee Ler,Lay Guat Ng,Wen-Hui Weng,Cheng-Keng Chuang,John SP Yuen,See-Tong Pang,Patrick Tan,Bin Tean Teh,Steven G Rozen

Genome Medicine（2015）

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摘要

Aristolochic acid (AA) is a natural compound found in many plants of the Aristolochia genus, and these plants are widely used in traditional medicines for numerous conditions and for weight loss. Previous work has connected AA-mutagenesis to upper-tract urothelial cell carcinomas and hepatocellular carcinomas. We hypothesize that AA may also contribute to bladder cancer.

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关键词

Bladder Cancer,Somatic Mutation,Bladder Tumor,Cosine Similarity,Aristolochic Acid

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