Lack Of Association Between The Atp13a2 A746t Variant And Parkinson'S Disease Susceptibility In Han Chinese: A Meta-Analysis

Purpose: To perform a meta-analysis to help resolve the controversy of whether the ATP13A2 A746T variant is associated with Parkinson's disease (PD) susceptibility in Han Chinese. Methods: Six literature databases were searched for case control studies published up to October 2014: Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang and SinoMed. Results: Five eligible articles were identified, which reported six case control studies and a total of 1703 cases and 2050 controls. The overall results suggested low frequencies of the A746T variant in Han Chinese patients (9/1703, 0.55%) and controls (6/2050, 0.29%). We failed to find evidence of significant differences in variant frequencies among Han Chinese, Uyghur and Japanese patients (p = 0.263). Analysis of pooled odds ratios (ORs) and 95% confidence interval (Cis) revealed no association between the A746T variant and overall PD risk (GA vs. GG: OR 1.78, 95%Cl 0.71-4.46, p = 0.216; allele A vs. G: OR 1.90, 95%Cl 0.77-4.69, p = 0.167). Conclusion: The ATP13A2 A746T variant is rare in Han Chinese patients and controls and is not associated with PD susceptibility in this ethnic group. Variant frequencies do not differ significantly among Han Chinese, Uyghur and Japanese patients. Further well -designed studies with larger samples are needed to validate these results.