Activation of autoreactive CD4+ T cells is synchronous to islet autoantibody seroconversion and shows an IFNγ signature

M Scholz,C Winkler,Sevina Dietz,A Eugster,A K Heninger,Donald M Kuhn, Ezio Bonifacio,A G Ziegler

Diabetologie Und Stoffwechsel（2014）

Cited 0|Views12

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Abstract

Islet autoantibody seroconversion is the first detectable evidence of autoimmunity preceding type 1 diabetes. Autoantibodies are markers of pre-diabetes, but T cells mediate beta cell destruction. Little is known about the timing of autoreactive T cell activation against beta cell antigens in the prediabetic period.

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Key words

Islet Autoimmunity,Type 1 Diabetes

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