Activation of autoreactive CD4+ T cells is synchronous to islet autoantibody seroconversion and shows an IFNγ signature
Diabetologie Und Stoffwechsel(2014)
Abstract
Islet autoantibody seroconversion is the first detectable evidence of autoimmunity preceding type 1 diabetes. Autoantibodies are markers of pre-diabetes, but T cells mediate beta cell destruction. Little is known about the timing of autoreactive T cell activation against beta cell antigens in the prediabetic period.
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Key words
Islet Autoimmunity,Type 1 Diabetes
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