TRIF promotes angiotensin II-induced cross-talk between fibroblasts and macrophages in atrial fibrosis

•Compared with SR, AF showed higher TRIF expression in left atrial appendage.•TRIF siRNA reversed macrophage chemotaxis induced by AngII-treated fibroblast.•TRIF siRNA reversed chemokines expressions induced by AngII in fibroblast.•AngII-stimulated atrial fibroblast proliferation was enhanced by macrophage.