Cutaneous Paraneoplastic Syndromes Associated With Lung Cancer: Dr. Patel replies

I appreciate Dr. Cohen's comments on our article. A comprehensive description of the cutaneous paraneoplastic syndromes associated with lung cancer is useful, although beyond the scope of the article. The list that Dr. Cohen has provided is helpful for reminding physicians to maintain a high index of suspicion for the protean manifestations of lung cancer at initial diagnosis or as an indication of metastatic growth or recurrence of disease. Cutaneous Paraneoplastic Syndromes Associated With Lung CancerMayo Clinic ProceedingsVol. 68Issue 6PreviewCutaneous paraneoplastic syndromes are a group of dermatoses that occur before, concurrent with, or after an associated malignant disease; in addition, some such dermatoses may be noted in persons who are free of cancer, either in association with a systemic disease or as an isolated dermatologic condition.1 Prompt diagnosis and appropriate evaluation of these conditions may enable the early detection of an otherwise asymptomatic internal neoplasm. Although the pathogenesis of many of these dermatoses remains undetermined, a postulated mechanism is that they are caused directly by a cytokine secreted by the tumor; alternatively, the neoplasm may participate indirectly by inducing accessory cells to secrete the causative factor. Full-Text PDF