Progression to treatment failure among Chinese patients with type 2 diabetes initiated on metformin versus sulphonylurea monotherapy—The Hong Kong Diabetes Registry

Guozhi Jiang,Andrea O. Luk,Xilin Yang,Ying Wang,Claudia H.T. Tam, Siu Him Lau,Risa Ozaki,Alice P.S. Kong,Peter C. Tong,Chun Chung Chow,Juliana C.N. Chan,Wing Yee So,Ronald C.W. Ma

Diabetes Research and Clinical Practice（2016）

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摘要

•A detailed analysis was conducted based on a large well-documented cohort.•Various potential sources of biases were considered when testing drug effects.•Multiple imputation, new-user design, and matching methods were systematically incorporated.•We found a lower treatment failure rate for metformin use in comparison with SU.

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关键词

Drug use bias,Diabetes,Treatment failure,Metformin,Sulphonylurea

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