High glucose and/or high insulin affects HIF-1 signaling by regulating AIP1 in human umbilical vein endothelial cells.
Diabetes Research and Clinical Practice(2015)
Abstract
•The first demonstration of a rapid increment in AIP1 synthesis in cells exposed to high glucose.•Insulin partially reverses the effect of high glucose on the expression of AIP1 and HIF-1α signaling.•Evidence of a possible relationship between AIP1 and HIF-1α signaling under high glucose.•AIP1 downregulation reduces apoptosis and promotes cell proliferation and migration along with tubule formation under high glucose.•AIP1 might be a key molecule involved in disordered signaling and impaired function of cells in diabetes.
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Key words
ASK1-interacting protein-1,PI3K/Akt/HIF-1α signaling,High glucose,High insulin,Apoptosis
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