Serum inhibitory and bactericidal titers in the clinical management of bacterial infections

Background The clinical management of bacterial infection computes factors related to bacteria (e.g., resistance profile [1]), antibiotics (e.g., activity spectrum, distribution volume, etc.), host characteristics (e.g., vascularization of the infected tissue, effectiveness of host defenses, etc.), as well as pharmacokinetic (PK) parameters [2]. The serum inhibitory (SIT) and bactericidal titers (SBT) are laboratory tests that simulate the interactions between antibiotics and bacteria in the human body milieu.