PLGA nanofibers improves the antitumoral effect of daunorubicin

•PLGA nanofibers loaded with daunorubicin (PLGA-DNR) were prepared by electrospinning process.•Sixty-five percent of the DNR was released in an initial burst over 8h and by 1224h, eighty-five percent of the DNR had been released, modelled by zero order kinetics.•In vitro experiments demonstrated that the PLGA-DNR nanofibers had a higher cytotoxic effect to A431 tumor cells than free DNR.•In vivo data showed that the nanofibers had an antiangiogenic effect, no inflammatory potential and decreased of the vascularization.