Improvement of Renal Function after Cyclosporine Reduction Is Influenced by Baseline Proteinuria in Patients Converted to Everolimus: Long Term Follow-Up of the Shirakiss Randomized Study

Cyclosporine (CsA) nephrotoxicity negatively impacts long-term management of heart transplant (HT) recipients. Thus, we designed the SHIRAKISS randomized study to compare two CNI lowering strategies on the progression of renal dysfunction (NCT00420537). Herein we report the 24 months outcome of the patients initially randomized in the study.