Abstract P227: Higher HIV Viral Load in HIV Positive Patients with Hyperglycemia in Miami, Florida

Introduction: Hyperglycemia is associated with insulin resistance, metabolic syndrome and depressed innate immunity, but it is also induced by trauma, infections and stress. Combined antiretroviral therapy (cART) is necessary for the control of HIV viral load and delayed disease progression, but hyperglycemia has been identified as one of the side-effects of some of the antiretroviral medications, namely the protease inhibitors. However, further research is needed to identify possible sources of hyperglycemia in HIV infection. Hypothesis: Hyperglycemia is directly associated with HIV disease progression measured by CD4 cell count and viral load, and with the use of protease inhibitors (PI). Methods: Secondary analysis was conducted on the de-identified observational database from a subset (n=270 participants) of the Miami Adult Studies in HIV (MASH) cohort. The variables analyzed were fasting glucose levels, receiving cART, use of protease inhibitors (PIs), age, gender, parameters of disease progression (...