Natural Antioxidant-Isoliquiritigenin Protects Heart Against Ischemia-Reperfusion Injury Via Activation Of Cardioprotective Signaling Pathways

P19: Natural Antioxidant-Isoliquiritigenin Protects Heart against IschemiaReperfusion Injury via Activation of Cardioprotective Signaling Pathways Xiaoyu Zhang1; Jingying Wang2; Wenguang Li3; Ji Li4 1 Lanzhou Univ, Sch of Basic Medicine Sciences, Lanzhou, China 2 Univ at Buffalo-SUNY, Buffalo, NY 3 Lanzhou Univ, Sch of Basic Medicine Sciences, Lanzhou, China 4 Univ at Buffalo-SUNY, Buffalo, NY Background: Isoliquiritigenin (ISL), a simple chalcone-type flavonoid, which is derived from licorice compounds and mainly present in foods, beverages and tobacco. ISL is a natural antioxidant. There is amount of evidence that reactive oxygen species (ROS) is a critical factor involved in cardiac damage and apoptosis associated signaling pathways during ischemia/reperfusion. We hypothesize that ISL as a natural antioxidant may protect heart against ischemic injury via scavenging ROS and regulating cardioprotective signaling pathways. Search: Advanced Search Go Circulation Home Subscriptions Archives Feedback Authors Help AHA Journals Home « Previous Article | Table of