Abstract 11082: Exome Sequencing Implicates the Burden of Rare Potassium Channel Variants in the Risk of Drug Induced Long QT Syndrome

Peter Weeke,Jonathan D. Mosley,David B. Hanna,Christian M. Shaffer,Jessica T. Delaney,Quinn S. Wells,Sara L. Van Driest,Jason H. Karnes,Christie Ingram,Yan Guo,Yu Shyr,Kris Norris,Prince J. Kannankeril,Andrea H. Ramirez,Joshua D. Smith, Elaine R. Mardis,Deborah A. Nickerson,Alfred L. George,Dan M. Roden

Circulation（2013）

Cited 23|Views22

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Abstract

Background: Drug-induced long QT syndrome (diLQTS) is associated with the potentially fatal arrhythmia torsades de pointes (TdP). The contribution of rare genetic variants to the underlying genetic...

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Key words

Genetics,Drugs,Potassium channel,Gene mutations,Arrhythmias, treatment of

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