Abstract 140: Hemodynamic Efficacy and Gas Exchange During Continuous Chest Compressions or 30:2 Compression-to-Ventilation Ratio During Mechanical CPR in a Porcine Model of Cardiac Arrest

Introduction: A compression-ventilation (C:V) ratio of 30:2 is recommended for adult cardiopulmonary resuscitation (CPR). Continuous chest compression (CCC) minimizes interruption of chest compression especially when the airway is protected. In the present study, we investigated the effects of 30:2 and CCC with fixed ventilation on hemodynamic efficacy and gas exchange in a porcine model. Hypothesis: Hemodynamic efficacy achieved in CCC is better than those in 30:2 mechanical CPR without a negative effect to the gas exchange. Methods: Ten male domestic pigs weighing 38±2 kg were utilized. Ventricular fibrillation was electrically induced and untreated for 7 mins. The animals were then randomized to receive CCC with fixed ventilation (CCC group) or 30:2 CPR (VC group). Coincident with the start of compression, the animals were mechanically ventilated at a rate of 10 breaths-per-minute in the CCC group or with a C:V ratio of 30:2 in the VC group. Defibrillation was attempted by a single 150 J shock. If resu...