Pon1 Q192r (Rs662) Genetic Variant And Response To Clopidogrel And Prasugrel

Jessica L. Mega,Sandra L. Close,Stephen D. Wiviott,Michael Man,Suman Duvvuru,Joseph Walker,Scott S. Sundseth,William L. Macias,Elliott M. Antman,Eugene Braunwald,Marc S. Sabatine

Circulation（2011）

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摘要

Background: Clopidogrel and prasugrel are pro-drugs requiring biotransformation into active metabolites. Multiple studies have validated the relationship between loss-of-function alleles in the CYP...

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Antiplatelet drugs, Pharmacogenetics

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