Stable Hemiaminals: 2-Aminopyrimidine Derivatives
MOLECULES(2015)
摘要
Stable hemiaminals can be obtained in the one-pot reaction between 2-aminopyrimidine and nitrobenzaldehyde derivatives. Ten new hemiaminals have been obtained, six of them in crystal state. The molecular stability of these intermediates results from the presence of both electron-withdrawing nitro groups as substituents on the phenyl ring and pyrimidine ring, so no further stabilisation by intramolecular interaction is required. Hemiaminal molecules possess a tetrahedral carbon atom constituting a stereogenic centre. As the result of crystallisation in centrosymmetric space groups both enantiomers are present in the crystal structure.
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关键词
stable hemiaminal, stable intermediate, crystal structure, 2-aminopyrimidine, nitrobenzaldehyde
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