Short interfering RNA- mediated suppression of specific tumor proteins results in a reduced viability of malignant pleuramesothelioma cell lines

Objectives: The incidence of the malignant pleural mesothelioma (MPM) remains to continue despite the well known risk factors and the worldwide launched prophylaxis. It remains to be an unique aggressive and bad treatable malignoma with only limited surgical and chemotherapeutic options despite an extended demand. Our study follows a new approach by siRNA mediated silencing of survival necessary proteins. In different cell lines of MPM the potency of siRNA application was evaluated under the question of supporting or revising existing therapeutic protocols in order to enhance the limited prognosis. siRNA provides by its highly sensitive features the possibility to knock out specific targets. Proteins which are involved in the replication of the cells and tumor specific survival proteins are promising therapeutic targets.