Synthesis of some substituted furan-2(5 H )-ones and derived quinoxalinones as potential anti-microbial and anti-cancer agents

In search for novel anti-cancer and anti-microbial agents with promising pharmacotoxicological profile, the synthesis of some substituted 4-halofuran-2(5 H )-ones ( 8a – l , 9 , 11 ) and derived halogenated quinoxalin-2(1 H )-ones ( 12a – d ) is described. Some of the halogenated furanones were readily oxidized to the corresponding 2-bromo-2-propenoic acids ( 13a – c ) with hydrogen peroxide in alkaline medium. Twenty-two compounds were preliminary tested for their in vitro activity against three bacteria and one fungus and revealed encouraging activity. On the other hand, three compounds were screened as anti-cancer agents using cell line panel protocol and 22 compounds were subjected to cycline-dependent kinases (CDKs) inhibition screening program but were inactive.