Influence of inflammatory reaction on blood concentration of cholesterol and other biochemical values with regard to cardiac muscle damage in rats

The ultrastructure of myocardium during experimentally induced acute pleuritis and role of lipid metabolism in the protection of cardiac muscle were investigated. The study was performed on 24 rats from Buffalo strain. In the study group, the experimental acute pleuritis was induced and the scraps of heart muscle were taken at the 24(th), 72(n)d and 120(th) h after the onset of inflammatory reaction. The measurements of total and fractionated (LDL, HDL) cholesterol, triglycerides, interleukin 4 (Il-4) and cortisol concentrations in blood were made at the same hours. The significant decrease in lipoprotein concentration and increase in Il-4 concentration during acute pleuritis were found in the group of rats with histopathologically confirmed myocardial cell damage.