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Anti-heparanase activity of ultra-low-molecular-weight heparin produced by physicochemical depolymerization

Oussama Achour,Nicolas Poupard,Nicolas Bridiau,Stephanie Bordenave Juchereau,Frederic Sannier,Jeanmarie Piot,Ingrid Fruitier Arnaudin,Thierry Maugard

Carbohydrate Polymers（2016）

Cited 21|Views17
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Abstract
•Production of ultrasonic Ultra Low Molecular Weight Heparin (usULMWH).•Innovative ultrasonic assisted radical depolymerization of heparin produced usULMWH.•usULMWH structure and biological activities were compared to others heparins.•usULMWH have high anti-heparanase activity and moderate anticoagulant activities.•usULMWH might be potential anti-angiogenic candidates for cancer therapy.
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Key words
Heparin,Ultrasonic-assisted radical hydrolysis,Heparinase I-catalyzed β-elimination,Glycol-split,Heparanase,Anti-angiogenesis
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