A fetal sheep model for studying compensatory mechanisms in the healthy contralateral kidney after unilateral ureteral obstruction

Alexander Springer,Klaus Kratochwill,Helga Bergmeister,Dagmar Csaicsich,Johann Huber,Bernd Mayer,Irmgard Muhlberger,Jens Stahlschmidt,Ramnath Subramaniam,Christoph Aufricht

Journal of Pediatric Urology（2015）

Cited 9|Views21

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Abstract

Using a transcriptomics approach, it was possible to identify a gene expression fingerprint of contralateral renal growth in a fetal UUO model. Further studies are warranted to validate those processes and to allow incorporation of this knowledge in new fetal diagnostic or even therapeutic strategies.

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Key words

Fetal uropathy,Sheep model,Signaling,Renoprotection,Stress response

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