Protective effects of ugonin K on hydrogen peroxide-induced osteoblast cell damage

Yuling Huang,Chiahsin Lee, Jyhfei Liao,Yenwenn Liu,Wenfei Chiou

Journal of Functional Foods（2015）

引用 7|浏览27

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摘要

•Ugonin K suppressed H2O2-induced ROS production and apoptosis.•Protective effects of ugonin K are stronger than Vit C, α-tocopherol and probucol.•Ugonin K suppressed cytochrome c, active forms of PARP, caspases-9 and 3 expression.•Activation of ER/Src signaling participates in the protective mechanism of ugonin K.•Post-treatment of ugonin K after H2O2 treatment recovered H2O2-induced cell death.

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关键词

Ugonin K,Reactive oxygen species (ROS),Osteoblasts,Apoptosis,Cytochrome c,Caspase

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