Sensitive detection of a serum biomarker based on peptide nucleic acid-coupled dual cycling reactions
Analytica Chimica Acta(2015)
摘要
•A new assay for direct serum detection of protein or hormone markers is developed.•PNA-coupled DNA cycling reactions with dual amplification is adopted.•The sensing system provides a detection limit of insulin as low as 1pM.•The assay of blood sample can discriminate GDM patients from the normal ones.
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关键词
Peptide nucleic acid,Strand displacement,Dual amplification,Insulin,Gestational diabetes mellitus
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