A protocol for evaluating the safety of herbal preparations in a rat model: the case of a supercritical fluid extract of Saw Palmetto
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS(2010)
摘要
Herbal extracts must be evaluated for their efficacy and safety. In vivo acute toxicity studies must consider the different mechanisms by which active compounds may elicit toxicological outcomes. Thus, a methodology to test general parameters related to acute toxicity responses in a murine model was developed, using a Saw Palmetto extract (HiPower (R)): adult male Sprague-Dawley rats were treated orally with two doses of HiPower (R) (the recommended dose for humans and a dose 10-fold higher) for 10 days, to examine general homeostatic parameters (hemogram and clinical chemistry) as well as morphological features of tissues involved in the response to xenobiotics ( liver, kidney, spleen, and lymphatic ganglia). None of the parameters analyzed underwent significant changes during treatment, suggesting that HiPower (R) displays a good safety profile for the period tested. This method may be adopted for testing the in vivo acute toxicity of herbal extracts.
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关键词
Saw Palmetto,safety profile,Sprague-Dawley rats,acute toxicity
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