Expression of Nucleotide-Binding Oligomerization Domain-Like Receptor in Oral Lichen Planus

Wonkwang Bone Regeneration Research Institute, Wonkwang University, Daejeon, Korea Cherubism is a skeletal dysplasia characterized by progressive, painless, bilateral and symmetric lesions limited to the jaws. The lesions subsequently begin to regress, fill with bone and remodel until age 30. Because cherubism is usually self-limiting, operative treatment may not be necessary. However, surgical intervention with curettage, contouring or resection may be indicated for functional or aesthetic reasons. Surgical procedures are usually performed when the disease not activated. Tissue engineering uses scaffolds as delivery vehicles for transplanted cells to restore function and replace damaged tissue. Tissue engineering using fibrin scaffolds as delievery vehicles can be restore function and replace damaged tissue on oral maxillofacial area. This is the first report of a successful esthetic restoration using autologous human bone marrow mesenchymal stem cell for cherubism patient after corticotomy and curretage on both mandibular lesions. Support: This research was supported by iPET, Ministry of Agriculture, Food and Rural Affairs (112092-03-2-HD020).