Synthesis of the Indolic Pentacyclic Core of Manadomanzamine A Following Biogenetically Based Strategies
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(2012)
摘要
Manadomanzamine A is a complex alkaloid isolated from a marine sponge that shows promising biological activities. A biosynthetic hypothesis is proposed and is used as a guideline for biomimetic approaches to the pentacyclic indole nucleus of manadomanzamine A. The rich chemistry of reactive C5 units such as glutaconaldehydes or aminopentadienals was exploited towards this end.
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关键词
Alkaloids,Natural products,Biomimetic synthesis,Polycycles
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