Electrophile-Mediated Reactions of Functionalized Propargylic Substrates
European Journal of Organic Chemistry(2015)
摘要
Metal-free halogen, chalcogen, or oxocarbenium ion mediated yne-carbonyl or yne-thioxo transformations of a range of N- and O-propargylic compounds have been studied. This investigation has led to the development of a mild, economic, and effective method for the synthesis of functionalized 4H-1,3-oxazines, 4H-1,3-thiazines, 4,5-dihydrothiazoles, and α-substituted enones. The structure of the propargylic substrate and the nature of electrophile influence both the outcome and regioselectivity of processes.
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关键词
Alkynes,Electrophilic addition,Cyclization,Nitrogen heterocycles,Sulfur heterocycles,Regioselectivity
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