Progress in the Synthesis of 2-Substituted Benzoxazoles Derivatives

2-Substituted benzoxazole derivatives play important roles in pharmaceuticals, pesticide and coordination catalysis, so the synthetic methods for 2-substituted benzoxazoles have been attracted widely. Recently, a series of efficient green methods such as microwave irradiation, water as solvent, solvent-free, combinatorial chemistry and transition metal catalysis etc. have been used to synthesize 2-substituted benzoxazoles derivatives. Based on different starting materials and different methods, the recent advances in synthesis of 2-substituted benzoxazole are reviewed.