Rencent Advances in Asymmetric Michael Addition Catalyzed by Chiral Bifunctional Thioureas

Asymmetric organocatalysis has been a frontier in the field of asymmetric catalysis. The comparable advantages, including mild reaction conditions, environment benign, and so on, render the organocatalytic reaction to possess some features of green chemistry. Chiral amino-thiourea organocatalyst, especially chiral bifunctional thiourea, has been shown excellent catalytic performance in a variety of asymmetric reactions. This review provides an overview of applications of chiral bifunctional thiourea in asymmetry Michael addition reaction, and the prospect and development are depicted finally.