唾液酸衍生物的合成进展
Chinese Journal of Organic Chemistry（2014）
Abstract
唾液酸是一类九碳糖,主要以糖脂或者糖蛋白的形式广泛分布于哺乳动物组织中,是脊椎动物细胞表面最重要的单糖.唾液酸可修饰的位点较多,目前已发展出成千上万的非天然唾液酸衍生物用于分子成像.尽管如此,非天然糖代谢工程方法还处于发展的初期,很多方面亟待发展和完善.结合本课题组的研究成果,着重介绍了唾液酸衍生物的合成进展.
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Key words
N-ACETYLNEURAMINIC ACID,INFLUENZA NEURAMINIDASE INHIBITORS,PARAINFLUENZA VIRUS TYPE-1,GLUCONO-DELTA-LACTONE,CHEMOENZYMATIC SYNTHESIS,BIOLOGICAL EVALUATION,CROSS-LINKING,NEU5AC2EN DERIVATIVES,ENZYMATIC-SYNTHESIS,MECHANISTIC PROBES
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