New developments in the application of optimal control theory to therapeutic protocols
Mathematical Biosciences(2016)
Abstract
•We present an optimization algorithm for the general problem with several therapies.•We are able to consider bounds for the controls.•Our mathematical tool easily allows variations in the approach.•We work within a general framework.
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Key words
Optimal control,Pontryagin’s Minimum Principle,Coordinate cyclic descent,Immune response,Pathogenic disease
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