Acute hypotension following treatment with prazosin

SummaryThe authors give details of 3 patients out of 33 hypertensives being treated with prazosin who developed acute hypotension after a single 2 mg. dose. They comment that patients only appear to be at risk for about 3 hours after the initial dose and recommend that before starting therapeutic doses of the drug a trial dose of 0.5 mg. prazosin should be given.