From Targets to Candidates: Emerging Strategies in Drug Discovery. Highlights from the Society of Medicines Research Symposium, Held on December 12th, 2013 - National Heart & Lung Institute
Drugs of the future(2014)
摘要
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147 Fragment-based drug discovery for allosteric sites, PPI’s... and the future . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147 Targeting protein−protein interactions using small-molecule fragments and an antibody platform . . . . . . . . . . . . . . . . . . . . . . 149 Antibodies as tools in NCE discovery . . . . . . . . . . . . . . . . . . . . . . . 150 Challenges and opportunities in allosteric enzyme inhibition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150 Phenotypic screening approaches for the discovery of novel antimalarials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151 Bicycles: high affinity bicyclic peptides from phage display libraries . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153 Leading into new spaces – strategies for lead generation in neuroscience medicinal chemistry . . . . . . . . . . . . . . . . . . . . . . . . 154 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155
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关键词
Drug discovery strategies,Targets,Allosteric sites,Antibodies,Antimalarials,Bicyclic peptides
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