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Simultaneous determination of subutinib and its active metabolite in human plasma by LC-MS/MS: Application to pharmacokinetic study.

Likun Ding,Lin Yang,Suning Chen,Jiankang Li,Aidong Wen

Journal of Chromatography B（2015）

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Abstract
•LC–MS/MS method was developed for determination of subutinib in human plasma.•It is successfully applied to pharmacokinetic study of subutinib.•This is first time to report the pharmacokinetic of subutinib maleate capsules.
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Key words
Subutinib,Active metabolite,LC–MS/MS,Pharmacokinetics
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