Impact of Vaccination: Health Impact and Cost-Effectiveness to Make Informed Policy Decision on the Introduction of Human Papillomavirus (Hpv) Vaccine to the National Immunization Program (Nip) in Thailand
Value in Health(2014)
Abstract
This study estimated health impact and cost-effectiveness of adding a quadrivalent HPV vaccination program for preadolescent girls to the existing cervical cancer screening program from the Thai payer perspective. A published transmission-dynamic model was adapted to Thailand setting. Both direct and indirect (herd immunity) benefits were captured by the model. Model inputs were obtained from literature, unpublished data and expert opinion. A proposed tender price of vaccine shown on recent news plus logistics, management and administration costs were used as vaccine-related costs to reflect the real situation of Thailand school-based HPV vaccination. Future costs and outcomes were discounted at 3%. Two vaccination strategies of combining cervical cancer screening with routine vaccination (11- to 12-year-old females) and with routine plus 5-year catch-up vaccination (13- to 24-year-old females) were compared to screening program alone. Adding HPV vaccination to the screening program provided both short- and long-term health benefits. Compared with current screening practice over 100 years, routine vaccination reduced cumulative incidence of cervical cancer (-54%), CIN1 (-71%), CIN2/3 (-70%), genital warts among females (-75%) and males (-63%), and cervical cancer deaths (-52%). Routine vaccination also resulted in reduction of disease costs for cervical cancer (-24%), CIN1 (-42), CIN2/3 (-41%), genital warts in females (-52%) and males (-42%). The reduction in HPV6/11-related disease incidence and costs avoided occurred relatively soon after vaccination, especially CIN1 and genital warts. Considering the recommended threshold of 160,000 THB/QALY, both routine and routine plus catch-up programs are cost-effective with discounted incremental cost-effectiveness ratios (ICER) of 35,124 and 34,426 THB/QALY, respectively. The ICER increased by about 31% for both strategies when HPV6/11-related effects were excluded. The school-based HPV vaccination program, using the quadrivalent HPV vaccine, is cost-effective, particularly when catch-up vaccination is incorporated. The results support decision-making process to include HPV vaccination in Thailand NIP.
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Key words
human papillomavirus,national immunization program,vaccination,vaccine,hpv,cost-effectiveness
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