Identification of the inositol 1,4,5-trisphosphate receptor type 1 as a new autoantigen of Purkinje cells

Introduction: Several neuronal autoantibodies target Purkinje cell antigens and can be determined by indirect immunofluorescence (IIF) using cryosections of rat, porcine, and primate cerebellum. They are generally associated with cerebellar ataxia and accompanied by an underlying tumour. Here we report a new autoantibody directed against inositol 1,4,5-trisphosphate receptor type 1 (IP3R1).