1278 URSODEOXYCHOLIC ACID COUNTERACTS LIPOTOXICITY AND INDUCES UNFOLDED PROTEIN RESPONSE IN MORBIDLY OBESE PATIENTS

Our findings demonstrate a novel role of Hedgehog signaling in lipid metabolism which dominates with a more periportal distribution, whereas depletion of APC leads to a pericentralization of hepatic functions, associated with reduced urea production and glutamine uptake.The increase in pyruvate uptake with simultaneously decreased citrate and alpha-ketoglutarate production implicates its use for fatty acid synthesis.Investigations on Hedgehog signaling have demonstrated a prominent role in lipid metabolism, which is also subject to liver zonation.